Research Article

Histopathological Effects of Three Types of Potash on the Hearts of Wistar Rats

Abstract

Potash (kanwa) is widely consumed in many African countries as a food additive despite concerns regarding its possible toxic effects on body organs. This study investigated the histopathological effects of three types of potash on the hearts of Wistar rats. The study was carried out in Ekpoma, Edo State, Nigeria using sixty (60) adult albinoWistar rats randomly assigned into control and experimental groups. The experimental groups received graded doses of potash (0.4g/ml, 0.6g/ml, and 0.8g/ml orally) for four weeks, while the control group received normal feed and water only. At the end of the experiment, the animals were sacrificed under chloroform anaesthesia and heart tissues were harvested for histological examination using Haematoxylin and Eosin staining techniques. The findings revealed varying degrees of histopathological alterations in the treated groups compared with the control group which showed normal cardiac architecture. The observed lesions included cellular necrosis, haemorrhage, oedema, vacuolations, vascular carbon deposits, and cytoarchitectural distortion of the cardiac tissues. The severity of tissue damage increased with higher concentrations of potash administration, with the highest dose producing the most pronounced pathological changes. These findings suggest that  prolonged consumption of potash may exert toxic and degenerative effects on cardiac tissues. The study concludes that excessive intake of potash could be harmful to the heart and may predispose individuals to cardiovascular abnormalities. Therefore, moderation in potash consumption is strongly recommended, while further studies are needed to evaluate its long-term functional effects on vital organs. 

Authors affiliation:

Julius Kayode Bankole (ORCID): 
Department of Histopathology and Cytopathology, Faculty of Medical Laboratory Science, College of Medical Sciences, Ambrose Alli University, Ekpoma, Edo State, Nigeria
Department of Histopathology and Cytopathology, Faculty of Medical Laboratory Sciences, College of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria. 

Ernest Asibor: 
Department of Histopathology and Cytopathology, Faculty of Medical Laboratory Science, College of Medical Sciences, Ambrose Alli University, Ekpoma, Edo State, Nigeria

Samuel Ifedioranma Ogenyi (ORCID):
Department of Histopathology and Cytopathology, Faculty of Medical Laboratory Sciences, College of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria

Ejeatuluchukwu Obi (ORCID): 
Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Nnamdi Azikiwe University, Awka, Nigeria

How to Cite: J.K. Bankole, E. Asibor, S.I. Ogenyi and E. Obi. Histopathological Effects of Three Types of Potash on the Hearts of Wistar Rats. Journal of Applied Health Sciences and Medicine, 6(7):1–16, 2026. https://doi.org/10.58614/jahsm671