Research Article

Design and Synthesis of Novel Gly-Tyro based Arylsulphonamoyl compounds as Anti-alzheimer’s and Antioxidant Agents

Abstract

Four novel glycine-tyrosine dipeptide sulphonamide deriavtives were synthesized, characterized via 1HNMR, 13CNMR, FTIR and HRMS spectroscopic techniques and their anti-alzheimer’s, antioxidant activities were investigated. The base promoted reaction of substituted benzenesulphonyl chloride with L-glycine gave compound (7a-7b) in excellent yields. Compounds (12a-12d) were achieved by amidation of substituted benzenesulphonamoyl derivatives with alkanamides (11) in the presence of EDC.HCl and HOBt as peptide coupling reagents. The antimicrobial properties were determined by agar dilution method and the antioxidant properties were also investigated. The anti-alzheimer’s study revealed that the IC50 value of compound 12c showed a significant inhibition of 0.65 mg/mL comparable with the IC50 value of galantamine (0.70 mg/mL). In the antioxidant study, IC50 value of compound 12b (0.76 mg/mL) is comparatively almost the same with that of vitamin C (0.79 mg/mL). This implies that compound 12b can be serve as a lead potent antioxidant agent. 

Authors affiliation:

Ike Ozoemena Christian (ORCID): Department of Industrial Chemistry, Enugu State University of Science and Technology, Enugu State, Nigeria.
Okoro Uchechukwu Christopher (ORCID): Department of Pure and Industrial Chemistry, University of Nigeria Nsukka, Enugu State, Nigeria.
Ogbuanu Cyril Chinedu: Department of Industrial Chemistry, Enugu State University of Science and Technology, Enugu State, Nigeria.

How to Cite: I.O. Christian, O.U. Christopher and O.C. Chinedu. Design and Synthesis of Novel Gly-Tyro based Arylsulphonamoyl compounds as Anti-alzheimer’s and Antioxidant Agents. Journal of Applied Health Sciences and Medicine, 6(6):18–23, 2026. https://doi.org/10.58614/jahsm664