Research Article

Anti-Inflammatory Activity of Organic Extract of Leaves of Sida Cordifolia Against Egg Albumin, Cotton Pellet-Induced Granuloma in Albino Wistar Rats

Abstract

Background: Sida cordifolia Linn is one of the most important tree species for the environment and commerce in arid and semi-arid parts of the world. Sida cordifolia is a member of the Malvaceae family.to assess the methanolic extract of dried Sida cordifolia Linn leaves’ anti-inflammatory properties. Methodology: Adult male Wistar rats weighing between 100 and 150 grams were used in this study. Healthy albino rats were administered Sida cordifolia Linn. methanolic extract orally at doses of 300 mg/kg for the egg albumin induced paw oedema model and 200 and 400 mg/kg body weight to evaluate the cotton pellet-induced granuloma approach. Results: The results of the egg albumin-induced paw oedema showed that the methanolic extract of Sida cardifolia leaves at 300 mg/kg−1 showed 55.80% inhibition, while idomethacin showed 56.09%. The results of the cotton pellet-induced granuloma showed that the extract of Sida cardifolia at 200 mg/kg−1 showed 26.3% inhibition, 40.5% inhibition, and idomethacin showed 45.5%. ANOVA and Dunnett’s test were used to examine the data, with significance set at p <0.05. Conclusion: Methanolic extract of Sida cordifolia Linn. Possesses analgesic activity in a dose-dependent manner in thermal induced model.

Authors affiliation:

Rambabu Boda (ORCID): Department of Pharmacology, AVANTHI Institute of Pharmaceutical Sciences, Hyderabad, India

How to Cite: R. Boda. Anti-Inflammatory Activity of Organic Extract of Leaves of Sida Cordifolia Against Egg Albumin, Cotton Pellet-Induced Granuloma in Albino Wistar Rats. Journal of Applied Health Sciences and Medicine, 6(6):12–17, 2026. https://doi.org/10.58614/jahsm663