Research Article

Qualitative Assessment for Kinetic Interactions of Caffeine Drug with Copper and Zinc Ions

Abstract

Practically, caffeine drug is checking as pure material by melting point and solubility for ensuring from purity of compound, before complete progress to known properties of caffeine. Then, the behave of caffeine drug in selected solvents was achieved, and the extension coefficient was determined depending on the obtained absorbance. The mathematical calculations were shown presence relationship between dielectric constant (ε0) of solvents with extension coefficient (ε) of caffeine drug. Caffeine drug has the highest value of extension coefficient (ε) in ethanol and the least value in hexane; as well as the electronic interactions in different solvents were π–π∗ transitions. The experimental data of caffeine drug in different acidity function were shown good solubility in acidic media (pH=5.0 – 6.0) compared with relative stability in basic media (pH=7.0 – 8.0), although the little change in maximum wave length (λmax). The spectral analysis of reactant molecules (caffeine drug and elements ions) at pH=7.4 and T=37◦C were showed identical values for the standards (λmax = 273; 242, 376 nm for caffeine, copper and zinc ions respectively). The spectral measurements of molecular complexes between caffeine drug and elements ions (at λmax = 238 and 270 nm for copper and zinc complexes  espectively) were regularity, and the spectral lines were followed as first order interactions. The mathematical calculations showed that, rate constant and half time of interaction caffeine drug with elements ions did not differ largely (for molecular complex of Cu2+ ions; k∗ =28.40 ×10–3min 1; t1/2=24.401 min, and for complex Zn2+ ions; k∗=24.00 ×10–3min–1; t1/2= 28.875 min). Therefore, interactions between caffeine drug and elements ions occurred spontaneously by van der Waals forces; and resulted molecular complexes forming and deforming continuously in aqeous solution.

Authors affiliation:

Razzaq Abd Al-Zahra Ibrahim (ORCID): Department of Biology, Faculty of Science, University of Kufa, Najaf - 54001, Iraq

How To Cite: R.A.A. Ibrahim. Qualitative Assessment for Kinetic Interactions of Caffeine Drug with Copper and Zinc Ions. Healthcare Issues, 5(2):34–41, 2026. https://doi.org/10.58614/hi526