Research Article

Synthesis and Investigations of Antimicrobial and Antioxidant properties of New Val-Tyro based Arylsulphonamoyl Dipeptide Carboxamide Derivatives

Abstract

Sulphonamides and carboxamides serve important roles in pharmacology. Four new dipeptide carboxamide derivatives with benzensulphonamide functionality were synthesized and their antibacterial, antioxidant activities were investigated. The base promoted reaction of substituted benzenesulphonyl chloride with L-valine gave compound (13a-13b) in excellent yields. Compounds (18a-18d) were achieved by amidation of substituted benzenesulphonamoyl derivatives with carboxamide derivatives (17) using peptide coupling reagents. The chemical structures were confirmed by FTIR, 1H-NMR, 13C-NMR and HRMS spectroscopic techniques. The antimicrobial properties were determined by agar dilution method and the antioxidant properties were also investigated. Compounds 18a, 18b and 18d was confirmed to be the most potent antibacterial agent that inhibited the growth of bacteria while Compounds 18a and 18c displayed the most active antifungal agent. Compound 18b and 18d showed the best antioxidant activities with IC50 value of 0.63 mg/mL and 0.64 mg/mL respectively. 

Authors affiliation:

Ike Ozoemena Christian (ORCID): Department of Industrial Chemistry, Enugu State University of Science and Technology, Enugu State, Nigeria.
Ogbuanu Cyril Chinedu (ORCID): Department of Industrial Chemistry, Enugu State University of Science and Technology, Enugu State, Nigeria.
Okoye Nebeolisa Johnson (ORCID): Department of Industrial Chemistry, Enugu State University of Science and Technology, Enugu State, Nigeria

How to Cite: I.O. Christian, O.C. Chinedu and O.N. Johnson. Synthesis and Investigations of Antimicrobial and Antioxidant properties of New Val-Tyro based Arylsulphonamoyl Dipeptide Carboxamide Derivatives. Healthcare Issues, 5(1):42–48, 2026.  https://doi.org/10.58614/hi517